A radical-pair quantum mechanism underlies MagLOV2 magnetosensitivity
A field-dependent, sign-changing response at low fields is a signature predicted by the radical-pair model — several Evidence nodes support this model.
· version frozen ·
raw data: request access
Evidence · supports a Claim · grounded in a Study
The magnetic-field effect in MagLOV2 flips sign as the field strengthens
In MagLOV2-expressing E. coli, the sign of the mean magnetic-field effect (MFE) flipped from positive to negative as magnetic field strength increased at low fields — positive near 0.5 mT, crossing zero, negative by ~2.5 mT. Measured by bacterioscope live fluorescence imaging across five field strengths.
What's in the dish
| Organism | E. coli |
| Reporter | MagLOV2 |
| Field strengths | 0.5–2.5 mT (×5) |
| Colonies | 74 per field |
| Modality | bacterioscope |
| Field cal. | Twinleaf magnetometer |
mean MFE ± SEM · n = 74 colonies/field
illustrative · unpublished — workshop prototype
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Evidence · this node
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MFE sign flipped from positive to negative as field strength increased
Across 0.5–2.5 mT, the mean magnetic-field effect was positive at low field, crossed zero, and turned negative by ~2.5 mT (1 experiment per field, 74 colonies each) — the curve above.
gitquantum-bio/mfe-analysis @ 7c1ae04 · /mfe_fit_analysis/
datacurated mfe_by_field.csv (this figure)
1 working note withheld by the authors — not part of this publication.
grounds ↑
Study → Evidence
Bacterioscope live imaging of MagLOV2 E. coli across 5 field strengths
One experiment, five imaging sessions on five days at 0.5, 1.0, 1.5, 2.0 and 2.5 mT; per-colony fluorescence tracked under a Twinleaf-calibrated applied field, with the MFE computed per colony.
rawNDTiff stacks · institute driverequest access
follows ↑
Study → Protocol
MagLOV2 expression + applied-field acquisition + per-colony MFE
Express MagLOV2 in E. coli; acquire fluorescence on the bacterioscope under an applied field calibrated with a Twinleaf magnetometer; compute the magnetic-field effect per colony and average across the plate.
gitquantum-bio/mfe-analysis @ 7c1ae04 · /protocols/bacterioscope_mfe.md